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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > Histamine Receptor H2 (aa309-323) Antibody (internal region)
Histamine Receptor H2 (aa309-323) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P25021 |
| Other Accession | NP_001124527.1, NP_071640.1, 3274 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 40098 Da |
| Gene ID | 3274 |
|---|---|
| Other Names | Histamine H2 receptor, H2R, HH2R, Gastric receptor I, HRH2 |
| Dilution | WB~~1:1000 E~~N/A |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Histamine Receptor H2 (aa309-323) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HRH2 |
|---|---|
| Function | G-protein coupled receptor for histamine, primarily mediating gastric acid secretion. Predominantly expressed in the gastric mucosa, couples to G(s) G alpha proteins upon histamine binding, leading to activation of adenylate cyclase and increased intracellular cyclic AMP (cAMP) levels (PubMed:38647423, PubMed:39333117). This signaling cascade stimulates parietal cells to secrete hydrochloric acid, playing a key role in digestive physiology. Also expressed in other tissues, including the heart and central nervous system, where it may contribute to cardiac stimulation and modulate neurotransmitter release (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. |
Research Areas
Citations ( 0 )
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize both reported isoforms (NP_001124527.1; NP_071640.1).
References
Histamine: its novel role as an endogenous regulator of Con A-dependent T cell proliferation. Nakane H, Sonobe Y, Watanabe T, Nakano K. Inflamm Res. 2004 Jul;53(7):324-8. PMID: 15241568
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$ 423.00
Cat# AF3587a
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